Saving the pharmacy of the sea: How does global change affect species with bioactive potential in the Mediterranean?


Several marine species in the Mediterranean produce molecules with bioactive potential that could be used to develop new drugs (antibiotics, antifungals, antivirals, and antitumourals). Different human activities such as pollution, marine recreation, and fishing, as well as climate change, threaten and even endanger some of these species. These vulnerable species with bioactive potential must be protected, especially in marine reserves, not only because they are valuable components of marine ecosystems, but also because they are a potential source of molecules with pharmacological properties that are currently being researched for the creation of new drugs.


global change; oceans; biodiversity; health; bioactive compounds

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  • Alexander, M. T., & Wigart, R. C. (2013). Effect of motorized watercraft on summer nearshore turbidity at Lake Tahoe, California–Nevada. Lake and Reservoir Management, 29(4), 247–256.

  • Boero, F., Brotz, L., Gibbons, M., Piraino, S., & Zampardi, S. (2016). 3.10 Impacts and effects of ocean warming on jellyfish. In D. Laffoley & J. M. Baxter (Eds.), Explaining ocean warming: Causes, scale, effects and consequences (pp. 213–237). IUCN.

  • Bonin-Font, F., Lalucat, J., Oliver-Codina, G., Massot-Campos, M., Font, E. G., & Carrasco, P. L. N. (2018). Evaluating the impact of sewage discharges on the marine environment with a lightweight AUV. Marine Pollution Bulletin, 135, 714–722.

  • Bordbar, L., Kapiris, K., Kalogirou, S., & Anastasopoulou, A. (2018). First evidence of ingested plastics by a high commercial shrimp species (Plesionika narval) in the eastern Mediterranean. Marine Pollution Bulletin, 136, 472–476.

  • Bruton, M. N. (1985). The effects of suspensoids on fish. Hydrobiologia, 125(1), 221–241.

  • Cabanellas-Reboredo, M., Vázquez-Luis, M., Mourre, B., Álvarez, E., Deudero, S., Amores, Á., Addis, P., Ballesteros, E., Barrajón, A., Coppa, S., García-March, J. R., Giacobbe, S., Casalduero, F. G., Hadjioannou, L., Jiménez-Gutiérrez, S. V., Katsanevakis, S., Kersting, D., Mačić, V., Mavrič, B., … Hendriks, I. E. (2019). Tracking a mass mortality outbreak of pen shell Pinna nobilis populations: A collaborative effort of scientists and citizens. Scientific Reports, 9(1), 13355.

  • Campos, F. V., Menezes, T. N., Malacarne, P. F., Costa, F. L. S., Naumann, G. B., Gomes, H. L., & Figueiredo, S. G. (2016). A review on the Scorpaena plumieri fish venom and its bioactive compounds. Journal of Venomous Animals and Toxins including Tropical Diseases, 22, 35.

  • Carreño, A., & Lloret, J. (en prensa). The vulnerability of fish and macroinvertebrate species with bioactive potential in a Mediterranean marine protected area. Aquatic Conservation: Marine and Freshwater Ecosystems.

  • Casoli, E., Nicoletti, L., Mastrantonio, G., Jona-Lasinio, G., Belluscio, A., & Ardizzone, G. D. (2017). Scuba diving damage on coralligenous builders: Bryozoan species as an indicator of stress. Ecological Indicators, 74, 441–450.

  • Cheung, W. W. L., Pitcher, T. J., & Pauly, D. (2005). A fuzzy logic expert system to estimate intrinsic extinction vulnerabilities of marine fishes to fishing. Biological Conservation, 124(1), 97–111.

  • Codarin, A., Wysocki, L. E., Ladich, F., & Picciulin, M. (2009). Effects of ambient and boat noise on hearing and communication in three fish species living in a marine protected area (Miramare, Italy). Marine Pollution Bulletin, 58(12), 1880–1887.

  • Coro, G., Vilas, L. G., Magliozzi, C., Ellenbroek, A., Scarponi, P., & Pagano, P. (2018). Forecasting the ongoing invasion of Lagocephalus sceleratus in the Mediterranean Sea. Ecological Modelling, 371, 37–49.

  • Derraik, J. G. (2002). The pollution of the marine environment by plastic debris: A review. Marine Pollution Bulletin, 44(9), 842–852.

  • Erena, M., Domínguez, J. A., Aguado-Giménez, F., Soria, J., & García-Galiano, S. (2019). Monitoring coastal lagoon water quality through remote sensing: The Mar Menor as a case study. Water, 11(7), 1468.

  • Hendriks, I. E., Tenan, S., Tavecchia, G., Marbà, N., Jordà, G., Deudero, S., Álvarez, E., & Duarte, C. M. (2013). Boat anchoring impacts coastal populations of the pen shell, the largest bivalve in the Mediterranean. Biological Conservation, 160, 105–113.

  • Katsanevakis, S., Coll, M., Piroddi, C., Steenbeek, J., Ben Rais Lasram, F., Zenetos, A., & Cardoso, A. C. (2014). Invading the Mediterranean Sea: Biodiversity patterns shaped by human activities. Frontiers in Marine Science, 1, 32.

  • Lloret, J., Biton-Porsmoguer, S., Carreño, A., Di Franco, A., Sahyoun, R., Melià, P., Claudet, J., Sève, C., Ligas, A., Belharet, M., Calò, A., Carbonara, P., Coll, M., Corrales, X., Lembo, G., Sartor, P., Bitetto, I., Vilas, D., Piroddi, C., … Font, T. (2019). Recreational and small-scale fisheries threaten vulnerable species in coastal and offshore Mediterranean waters. ICES Journal of Marine Science, 77(6), 2255-2264.

  • Lloret, J., Garrote, A., Balasch, N., & Font, T. (2014). Estimating recreational fishing tackle loss in Mediterranean coastal areas: Potential impacts on wildlife. Aquatic Ecosystem Health & Management, 17(2), 179–185.

  • Milazzo, M., Badalamenti, F., Ceccherelli, G., & Chemello, R. (2004). Boat anchoring on Posidonia oceanica beds in a marine protected area (Italy, western Mediterranean): Effect of anchor types in different anchoring stages. Journal of Experimental Marine Biology and Ecology, 299(1), 51–62.

  • Natalotto, A., Sureda, A., Maisano, M., Spanò, N., Mauceri, A., & Deudero, S. (2015). Biomarkers of environmental stress in gills of Pinna nobilis (Linnaeus 1758) from Balearic Island. Ecotoxicology and Environmental Safety, 122, 9–16.

  • Nieto, F. R., Cobos, E. J., Tejada, M. Á., Sánchez-Fernández, C., González-Cano, R., & Cendán, C. M. (2012). Tetrodotoxin (TTX) as a therapeutic agent for pain. Marine Drugs, 10(2), 281–305.

  • PharmaMar. (2020, 16 de marzo). PharmaMar anuncia resultados positivos de Aplidin® contra el coronavirus HCoV-229E.

  • Pipitone, C., Badalamenti, F., D’Anna, G., & Patti, B. (2000). Fish biomass increase after a four-year trawl ban in the Gulf of Castellammare (NW Sicily, Mediterranean Sea). Fisheries Research, 48(1), 23–30.

  • Potera, C. (2007). Florida red tide brews up drug lead for cystic fibrosis. Science, 316(5831), 1561–1562.

  • Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005). Marine natural products as anticancer drugs. Molecular Cancer Therapeutics, 4(2), 333–342.

  • Trainer, V. L., & Hardy, F. J. (2015). Integrative monitoring of marine and freshwater harmful algae in washington state for public health protection. Toxins, 7(4), 1206–1234.

  • Uriz, M. J., Martin, D., Turon, X., Ballesteros, E., Hughes, R., & Acebal, C. (1991). An approach to the ecological significance of chemically mediated bioactivity in Mediterranean benthic communities. Marine Ecology Progress Series, 70(2), 175–188.

  • Verdura, J., Linares, C., Ballesteros, E., Coma, R., Uriz, M. J., Bensoussan, N., & Cebrian, E. (2019). Biodiversity loss in a Mediterranean ecosystem due to an extreme warming event unveils the role of an engineering gorgonian species. Scientific Reports, 9, 5911.

  • Zahn, R. K., Zahn, G., Müller, W. E. G., Müller, I., Beyer, R., Müller-berger, U., Kurelec, B., Rijavec, M., & Britvić, S. (1977). Consequences of detergent pollution of the sea: Effects on regenerating sponge cubes of Geodia cydonium. Science of The Total Environment, 8(2), 109–151.

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