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The RNA World: Piecing together the historical development of a hypothesis

Antonio Lazcano

Abstract


The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein synthesis and biochemical reactions took place. As the understanding of RNA biology progressed, several independent proposals of protein-free primordial life forms were suggested. Although this possibility was strongly reinforced with the discovery of ribozymes, there are many definitions of the RNA world, including several contradictory ones. One could say that it was an early, perhaps primordial, stage during which RNA molecules played a much more conspicuous role in heredity and metabolism and, particularly, in the origin and early evolution of protein biosynthesis. The overwhelming evidence for the catalytic, regulatory, and structural properties of RNA molecules, combined with their ubiquity in cellular processes, can only be explained with the proposal that they played a key role in early evolution and perhaps in the origin of life itself.

Keywords


Origin of life; RNA World; ribonucleotidyl coenzymes; catalytic RNA

Full Text: PDF

DOI: https://doi.org/10.7203/metode.6.5146

References


Bada, J. L., & Lazcano, A. (2003). Prebiotic soup: Revisiting the Miller experiment. Science, 300, 745–746. doi: 10.1126/science.1085145

Belozerskii A. N. (1959). On species specificity of nucleic acids in bacteria. In A. I. Oparin, A. G. Pasynskii, A. E. Braunshetin, & T. E. Pavloskaya (Eds.), The origin of life on Earth (pp. 322–331). New York: Pergamon Press/MacMillan Company.

Brachet, J. (1959). Les acides nucléiques et l’origine des proteins. In A. I. Oparin, A. G. Pasynskii, A. E. Braunshetin, & T. E. Pavloskaya (Eds.), The origin of life on Earth (pp. 361–367). New York: Pergamon Press/MacMillan Company.

Crick F. H. C. (1968). The origin of the genetic code. Journal of Molecular Biology, 39, 367–379.

Eakin, R. E. (1963). An approach to the evolution of metabolism. Proceedings of the National Academy of Sciences, 49, 360–366. Gilbert, W. (1986). The RNA World. Nature, 319, 618. doi: 10.1038/319618a0

Handler, P. (1963). Evolution of the coenzymes. In A. I. Oparin (Ed.), Proceedings of the Fifth International Congress of Biochemistry, Vol. III. Biochemistry (pp. 149–157). New York: Pergamon Press/Macmillan Company.

Lazcano, A. (2012). The biochemical roots of the RNA world: From zymonucleic acid to ribozymes. History and Philosophy of the Life Sciences, 34, 407–424.

Maurel, M. C., & Ninio, J. (1987). Catalysis by a prebiotic nucleotide analog of histidine. Biochimie, 69, 551–553.

Oparin, A. I. (1938). The origin of life. New York: MacMillan.

Oparin, A. I., Pasynskii, A. G., Braunshetin, A. E., & Pavloskaya, T. E. (Eds.). (1959). The origin of life on Earth. New York: Pergamon Press/MacMillan Company.

Orgel, L. E. (1968). Evolution of the genetic apparatus. Journal of Molecular Biology, 38, 381–393.

Orgel, L. E., & Sulston, J.E. (1971). Polynucleotide replication and the origin of life. In A. P. Kimball, & J. Oró (Eds.), Prebiotic and biochemical evolution (pp. 89–94). Amsterdam: North-Holland.

Rich, A. (1962). On the problems of evolution and biochemical information transfer. In M. Kasha, & B. Pullman (Eds.), Horizons in biochemistry (pp. 103–126). New York: Academic Press.

White III, H. B. (1976). Coenzymes as fossils of an earlier metabolic state. Journal of Molecular Evolution, 7, 101–104.

Woese, C. R. (1967). The Genetic Code: The molecular basis for gene expression. New York: Harper and Row.


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